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Group A: They have good evidence to support their claims of benefit in specific scenarios
Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization

doi: 10.3389/fphys.2020.609103 Received 22 September 2020 Accepted 24 December 2020 Published 20 January 2021 Volume 11 - 2020 Edited by Lars Kaestner, Saarland University, Germany Reviewed by Mauro Magnani, University of Urbino Carlo Bo, Italy
Reversible S-glutathionylation of Cys374 regulates actin filament formation by inducing structural changes in the actin molecule

BMC Cell Biol 2009
A major reason stems from published papers involving small sample sizes that inevitably result in a lack of specificity and higher variation
