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Benito-Martn, M.G

In a zeta class GST of Homo sapiens , the GSH thiolate is stabilized by interaction with Cys-16, Ser-15, Gln-111, and Ser-14 [73]

Moreover, HSV-1 infection enhances the E3 ubiquitin ligase Keap1 (Kelch-like ECH-related protein 1)-mediated ubiquitination and degradation of nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates the expression of antioxidative genes, thereby disturbing cellular redox homeostasis and promoting ferroptosis

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