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Antimicrob Agents Chemother 52: 183191

doi: 10.1016/j.fct.2019.110668

This excitatory-inhibitory dysregulation is further implicated in the frequent co-occurrence of tinnitus with anxiety and sleep disorders, suggesting shared neurobiological substrates involving maladaptive auditory-limbic network connectivity and neurotransmitter imbalances (Jiang et al., 2025)

The level of metalloproteins in the plasma is increased, and the level of RAS proteins is decreased, which results in the activator protein-1 (AP-1), by PI3K/Akt, JNK, p38 MAPK, and ERK signaling pathways [73]

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Their antimicrobial and anti-inflammatory properties make them valuable candidates for combating resistant infections and modulating inflammatory pathways