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Therefore, targeting autophagy regulation may represent a potential strategy to interrupt this pathological transformation

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First, a seemingly dramatic change in the unbound fraction from 1% to 10% releases less than 5% of the total amount of drug in the body into the unbound pool because less than one third of the drug in the body is bound to plasma proteins even in the most extreme cases, eg, warfarin

Finley and Davis, 1999)

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