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In a related study, when C57BL/6J mice, rendered diabetic by STZ, were treated for 8 weeks with GABA (250g/kg), blood glucose concentrations declined in concert with a ~3-fold increase in plasma insulin, yet plasma glucagon was unaltered
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Collectively, these findings confirmed that LBP could treat DCM by inhibiting inflammation and OS, likely through the suppression of Calpain-1 expression and NF-B activity
