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It was found that lignan, 3,3-bisdemethylpinoresinol exhibited potent inhibition of intracellular MMP-1 expression in UVA-irradiated normal human dermal fibroblasts

OGrady JG, Alexander GJ, Hayllar KM, Williams R

Here the original carbon skeleton R has been altered so that the new backbone R 1 carries additional functional groups (e.g., carbonyls, alcohols, or extra nitrate groups)

These pathways primarily involve organelle damage, ion channel abnormalities, cytoskeletal structure and axon degeneration, neuroinflammation, cellular dysfunction, and central nervous system (CNS) dysfunction

Environ Health Eng Manag 6(4):277282

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