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[DOI] [PubMed] [Google Scholar] 53.Pande M, Flora SJS

High levels of HO inactivate protective peptides like ACTH and -MSH, while decreasing enzyme activities like methionine sulfoxide reductase, consequently intensifying oxidative damage and accelerating melanocyte death 46

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However, there is an alternative mechanism for proteasomal degradation of Nrf2 independent of Keap1, which is mediated by glycogen synthase kinase 3 (GSK3) and -TrCP (Figure 1B)