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The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells

[DOI] [PubMed] [Google Scholar] 5.Monaca C., Franco P., Philip P., Dauvilliers Y

Weve seen many examples of GTPases in other chapters of this textbook, including the following: Ran, which helps proteins to enter/exit the nucleus (Chapter 3) Rabs, which help with vesicle docking (Chapter 4) GTPases, which are part of the vesicle coat (such as Arf and Sar) and help the coat fall off after the vesicles form (Chapter 4) Tubulin, a very distant relative of Ras that works in a very similar way (Chapter 6) The reason that we call these proteins molecular switches is that they have an on and off conformation, which is determined by the presence of GDP (off) or GTP (on)