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United States Department of Agriculture

Jakimovski D, Kavak KS, Zakalik K, et al

Consequently, dopamine neurons exhibit dopamine reuptake and are unable to transport dopamine back into the cells, and loss of dopamine neurons occurs [157]

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Critical safety considerations for laboratory use include potential immunogenicity concernswith peptide therapeutics commonly showing injection site reactions (20-40% with subcutaneous administration) and possible antidrug antibody formationalong with theoretical concerns that pro-angiogenic properties could potentially influence experimental tumor models, requiring appropriate controls in oncology-related research

Ribas A, 2019, 'Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001', Annals of Oncology , 30, pp