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Importantly, macrophages, which express and upregulate apoE during atherosclerosis, play critical roles in regulating vascular inflammation and lipid homeostasis [106]

Apart from one patient, all were identified by whole-exome sequencing or through candidate gene panels [3]

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Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats

Early diagnosis through genetic testing and metabolic screening is crucial, as prompt treatment with parenteral hydroxocobalamin, often combined with other adjunct therapies, can mitigate disease progression and improve outcomes