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It is also important to note that no safety issues can be detected when consuming creatine long-term [62,63]

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However, it is noteworthy that there is no significant correlation between serum and cerebrospinal fluid IGFs concentrations[69] and therefore, it seems that systemic IGFs are not a major source of IGFs for CNS

Biomark Med 8:321330 Tschinkel PFS, Bjrklund G, Conn LZZ, Chirumbolo S, Nascimento VA (2018) Plasma concentrations of the trace elements copper, zinc and selenium in Brazilian children with autism spectrum disorder
