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Protein Modification with Ribose Generates N(delta)-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine

Our roGFP2 measurements confirm (i) that dynamic roGFP2 sensing (or the physiological glutathionylation/deglutathionylation of regular surface-exposed cysteinyl residues) requires a glutaredoxin activity, and (ii) that glutathionylated proteins or metabolites should be very transient redox species when GSH and glutaredoxins are present (unless they are stabilized by a kinetic uncoupling mechanism) 5,32,34,35,6164

However, lower levels of ROS can be advantageous and are implicated in a variety of signaling pathways

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Nitric oxide, cell bioenergetics and neurodegeneration

The average survival rates (the number of living cells in NHS/the number of living cells in HIS) were calculated and the results are represented as the mean of survival rates standard error of the mean (SEM)