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Emerging evidence suggests that ALC levels are reduced in individuals with MDD, and this deficiency may contribute to depressive symptoms through disruptions in mitochondrial fatty acid transport, neuroplasticity, and neurotransmission

Despite a series of positive findings on the beneficial therapeutic target for various cardiovascular diseases derived from the evidence from clinical trials, there is still an urgent need for more meaningful, well-designed, randomized controlled trials to better define cardiovascular pharmacotherapy, the safe window of L-carnitine, and the longer-term side effects, including potential atherosclerotic effects

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Renal reabsorption of carnitine is the primary means of compensating for dietary carnitine deficiencies

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