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In contrast, in diseases characterised by mitochondrial dysfunction and bioenergetic failure (often reflected by reduced FDG-PET signal), elevated iron may instead represent a compensatory response to functional iron deficiency rather than a pathogenic surplus

( b-c ) Cells were transduced with shRNAs targeting TMLHE (shTMLHE)

In the early stages, apoptosis is marked by cell shrinkage, chromatin pyknosis (condensation), a reduction in cell volume and an increase in cytoplasmic density, along with more compact organelles (101,104)

Elevated Energy Expenditure Preclinical findings demonstrate higher energy expenditure and greater fat oxidation in obese models

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