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10.1242/DEV.129.15.3533 35 SteptoeP

IP3 may trigger the release of calcium ions (Ca2+) from intracellular stores, while DAG may activate protein kinase C (PKC)

In preclinical models this combination showed an additive effect

In novel object recognition and T-maze testing, R6/1 mice given IN-PACAP had significantly reduced memory deficits and increased hippocampal VGlut-1 and PSD95 expression [202]

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doi: 10.4049/jimmunol.172.9.5356
