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Heat therapy helps regulate the autonomic nervous system, contributing to better stress management, emotional balance, and sleep quality

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doi: 10.1038/s41598-018-22081-7

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doi: 10.1016/j.cell.2014.01.007

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The cGMP that is produced via NO activation of soluble guanylate cyclase (sGC) in this tissue is degraded by a specific cyclic nucleotide phosphodiesterase (PDE) identified as PDE5A

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