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Gently swirl/roll until dissolvedsolution should be clear (do not shake)

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Stop and Seek Help If Severe allergic reaction (rash, swelling, difficulty breathing) Persistent severe nausea or vomiting not improving with dose reduction Signs of pancreatitis (severe abdominal pain radiating to back) Planned pregnancy or positive pregnancy test Inability to maintain adequate nutrition despite dose adjustments Any concerning symptoms your healthcare provider advises stopping for Always consult your healthcare provider before stopping or modifying your dose

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Preparation of antibody-targeted particles The chemically modified PEG lipid, DSPE-PEG 2k-maleimide (#880126 P, Merck), was added to the lipid component at 1:3 molar ratio of DSPE-PEG 2k-maleimide to DMG-PEG 2k