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Direct effects on cellular proliferation A genetically engineered murine model of pancreatic intraepithelial neoplasia (PanIN) to PDAC progression ( LSL-Kras G12D ;Pdx1-Cre, KC ) treated with exenatide demonstrated architectural changes of loss of polarity and micropapillary formation following 12 weeks of therapy 18

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Common side effects of B12 injections include pain or discomfort at the injection site, mild gastrointestinal discomfort, headaches, and dizziness

doi: 10.1111/exd.14073

Equipment Required Drawing-up needle: 18G or 21G a wider bore draws viscous oil from the ampoule or vial efficiently Injecting needle: 21G to 23G (length determined by your body composition your clinic nurse will advise) always change to a fresh needle after drawing up Luer-lock syringe (1 ml or 2 ml as appropriate) the locking fitting prevents the needle detaching under oil pressure Sterile alcohol swabs Sterile cotton ball or gauze Approved yellow-lidded sharps bin (BS EN ISO 23907) Clean, flat surface wiped with an alcohol swab before use Inspect the ampoule or vial before every injection