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As the [NADP + ]/[NADPH] ratio, in both the cytosol and the mitochondria, increases with aging the activities of glutathione-disulfide reductase (encoded by the GSR gene

This in turn causes the thyroid to churn out an excess of thyroid hormones, leading to the hyperthyroidism of Graves disease

Laron Z: Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 19582003

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Long non-coding RNA NORAD contributes to the proliferation, invasion and EMT progression of prostate cancer via the miR-30a-5p/RAB11A/WNT/-catenin pathway

The mechanistic data summarized here derive largely from in vitro cell-culture systems and rodent models