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Wang ZY, et al

A number of enzymes are inhibited by high levels of acyl-CoA compounds, including acetyl-CoA carboxylase, adenine nucleotide translocase, and pyruvate dehydrogenase and can contribute to metabolic inflexibility

In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)

Importantly, some limitations of this study need to be addressed

One millilitre of arterial blood was placed into a heparin anticoagulation tube, and blood gas analysis was performed within 5 min

doi: 10.1017/S0967199409990311 [DOI] [PubMed] [Google Scholar] 116