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New York: McGraw Hill, pp

A direct comparison in mice demonstrated that sequential prime-boost vaccination with their three constructs (6 vaccinations in total) induced a stronger antibody response than simultaneous vaccination (prime and then boost with a mixture of all three, 2 vaccinations in total) [149]

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To eliminate this, same authors proposed Minimally invasive surgical technique (MIST) to limit the mesio-distal extension of the flap, and corono-apical flap reflection to increase flap stability [73]

This is a result of both the pigment shift and the general reduction in oxidative stress, which keeps skin cells looking healthier for longer