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The structureactivity relationships of flavonoids as inhibitors of xanthine oxidase and as scavengers of the superoxide radical [80] showed that the presence of hydroxyl groups at carbons 5 and 7 and the double bond between carbons 2 and 3 is essential for a high inhibitory activity on xanthine oxidase

Some xenobiotics, such as fibrate drugs, cause liver cancers when chronically administered to rodents, while humans have no risk of cancer by fibrates 26,27

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Piancatelli D., Aureli A., Sebastiani P., Colanardi A., Del Beato T., Del Cane L., Sucapane P., Marini C., Di Loreto S