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We hypothesized that patients with stable schizophrenia would exhibit a reduction in glutathione, glutamate, and/or glutamine in the cerebral cortex, consistent with a post-inflammatory response, and that this reduction would be most marked in patients with residual schizophrenia, in whom an early stage with positive psychotic symptoms has progressed to a late stage characterized by long-term negative symptoms and impairments

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Tong KI, Katoh Y, Kusunoki H, Itoh K, Tanaka T, Yamamoto M

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Swan, Pamela D (2006)