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The fumarate accumulation, which occurs as a consequence of FH mutations, results in the formation of hereditary papillary renal carcinomas, whereas the succinate accumulation, that occurs as a consequence of SDH mutations, results in the formation of hereditary paragangliomas (PGLs)

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It is a synthetic compound derived by modifying the structure of -tocopherol, replacing its hydrophobic polyisoprenoid tail with a hydrophilic carboxyl group

For a higher degree of purity, or in the unavailability of a suitable ligand for affinity purification, an efficient multi-step process must be developed using the purification strategy of Capture, Intermediate Purification, and Polishing (Cipp)

Novel insights into the pathogenesis of human post-primary tuberculosis from archival material of the pre-antibiotic era, 19311947
