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10.1186/s12915-015-0201-x 51 LaF

10.4039/ent129907-5 24 BurmanR

Mills, T

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This evidential gapwhere symptom improvement is confirmed but reproductive benefit remains unknownclearly defines the critical breakthrough direction for future translational research: there is an urgent need to establish a multidimensional evaluation system integrating objective microenvironmental markers (e.g., seminal plasma inflammatory cytokines/oxidative stress markers)semen quality/DFIreproductive outcomes. This is essential to definitively validate the clinical value of microenvironment remodeling interventions in preserving male fertility

Age-related alterations in this methylation pattern impair Treg activity, leading to dysregulated immune tolerance and contributing to the proinflammatory milieu associated with aging