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It exists as a pre-formed heterotetramer of two extracellular alpha subunits and two transmembrane beta subunits linked by disulfide bonds
[DOI] [PubMed] [Google Scholar] Francioso A, Fanelli S, Cavallaro RA, Fontana M, Mattioli R, DErme M, Mosca L
(2017) 356:eaaj2239
10.18632/aging.205777 34 FormanH
Additionally, combining UA with oleanolic acid can down-regulate the MMPs pathway to inhibit colon cancer (HT-29 and SW620) cell migration and enhance cancer cell death by inducing mitochondrial autophagy [1067]
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