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Fecchio C, Palazzi L, de Laureto PP (2018) alpha-Synuclein and polyunsaturated fatty acids: molecular basis of the interaction and implication in neurodegeneration

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A likely mechanism is that matrix swelling causes rupture of the outer membrane and release of the intermembrane proteins63

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The disorder is caused by a germline mutation in the RET gene, which encodes a receptor tyrosine kinase involved in cellular growth and differentiation