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Nitrosative stress-induced S-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response

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Short-chain fatty acids matter most here: butyrate in particular fuels the cells lining the colon and helps reinforce the tight-junction proteins that control what passes between cells (Koh et al., 2016)

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Targeting tissue-infiltrating immune cells has been shown to be efficacious in mitigating organ damage (160)

While these findings highlight promising biological activity, it is important to emphasize that current evidence is derived primarily from experimental animal models