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That is why the mechanism is described as plausible rather than speculative

BPC-157 appears to act upstream of VEGF transcription, with documented upregulation of VEGF mRNA and protein expression in both in vitro endothelial cell cultures and in vivo wound models

No adverse effects were noted in clinical trials (ulcerative colitis, phase II) [84,85], and in toxicological studies, a lethal dose (LD1) was not achieved (for review, see [11,12,13,14,24,25])

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