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They stimulate signaling pathways that enhance the cell's intrinsic antioxidative defenses, leading to a more robust response against oxidative stress [125]

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When used in therapeutic amounts, the toxic metabolite is detoxified by attaching to the sulfhydryl group of glutathione (GSH)

[Google Scholar] Kawano M, Takagi R, Kaneko A, Matsushita S (2015) Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses

Furthermore, we found a downregulation of glycolysis, a central pathway for glucose metabolism
