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Biosynthesis of glutamate and GABA: the glutamate/GABA-glutamine cycle Glutamate and GABA do not cross the blood-brain barrier and must therefore be synthesized within the CNS

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[DOI] [PMC free article] [PubMed] [Google Scholar] Jiang H, Ren Y, Zhao J, Feng J

The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans

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Its ability to influence gene expressionreportedly altering the activity of thousands of genesprovides a powerful model for investigating how cellular function can be modulated towards a regenerative state