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Furthermore, we observed that NTAPP induced the activation of -catenin in DP cells of hair follicles and the mRNA levels of target genes of the -catenin signaling pathway (CCND1, LEF1, and TCF4)

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By contrast, the inhibition of the de novo synthesis of GSH, by deleting either the catalytic (Gclc) or the modifier (Gclm) subunit of glutamatecysteine ligase (Gcl), dampens intracellular GSH, increases ROS, and impact T cell differentiation