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The Brain On Fire Shungus 2012 study found an an alarming (36%) decrease in the bodys chief antioxidant, glutathione (GSH), in the cortical regions of the brain

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The oxidative stress in mitochondria could be counteracted by IDH1-driven reductive carboxylation in the cytosol, followed by the transfer of citrate into the mitochondria, which was to be oxidized by IDH2 to generate NADPH [104]