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In our recent study [166], a single dose and repeated doses of ceftriaxone, a beta-lactam antibiotic that acts by upregulating GLT-1 expression, thus increasing glutamate reuptake in the CNS [167,168,169], was tested for its ability to attenuate early-phase and late-phase tactile allodynia and cold hyperalgesia in oxaliplatin-treated mice

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The researchers reported that administering the peptide to mice reduced CGRP-induced plasma protein extravasation (PPE), indicating the antagonistic effects of the peptide in vivo

10.1186/s12935-021-01886-z Cancer Cell Int

Progression of the cell cycle and proliferation sustained are two hallmarks of cancer that have an essential role in normal cells transforming into cancerous ones and the progression of the tumor (Hanahan and Weinberg, 2000)