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The prodromal motor period follows, during which, mild motor symptoms first become noticeable

Neurosci Biobehav Rev 2008

On reading the title and abstract of the resulting articles, 27 were excluded, as they did not meet the inclusion criteria (see Figure 1 )

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Researchers have found that TRPM3 channels are strongly inhibited by peripheral mu-opioid receptor activation.[ref] This may be the connection as to why LDN helps some people with ME/CFS.[ref open access, worth reading] A 2024 study explains that TRPM3 dysfunction in natural killer cells may be at the root of the ineffective pathogen clearance seen in some ME/CFS individuals

Why ARA-290 Is Different from Erythropoietin Erythropoietin: Increases red blood cell production Raises hematocrit Increases thrombosis risk at high levels ARA-290: Does not affect red blood cells Does not raise hematocrit Does not increase clotting risk This distinction makes ARA-290 suitable for chronic use in inflammatory and neurologic conditions , where EPO would be unsafe