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Rather than assessing the overall protein adduct formation in the cell, which was initially considered to be critical for cell death20, it now appears that protein adduct formation on mitochondrial proteins is most relevant for toxicity2123

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The role of lactate metabolism and lactylation in pulmonary arterial hypertension

However, the T-DXd objective response rate (ORR) of 55% (24) suggests that there is still a need for improved therapeutic options for patients with cancer with HER2 mutations

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After treatment with INH, RIF, and pyrazinamide alone or in conjunction with immunomodulator drugs (such as all- trans retinoic acid, vitamin D3, and -galactose amide), a notable decrease in Mtb burden and TB recurrence rate, and a shortened treatment course were observed in PTB mice (Mourik et al., 2017)