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C.CorvinoV.MarcheseE.SerranoA.MichettiF.DambrosiN

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doi: 10.1128/spectrum.03934-22 194 ZhaiB.OlaM.RollingT.TosiniN

No pharmaceutical company has funded the human clinical trials required for FDA approval

Once the hepatotoxicity due to APAP was recognized, the mechanisms behind this were extensively investigated, especially in the mouse model, which recapitulates key mechanistic aspects of liver injury in humans such as mitochondrial dysfunction [5,6]

Its gastric origin contributes to its unusual stability in acidic conditions
