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doi: 10.1152/ajpgi.1989.256.3.G517

it can cause numbness, tingling, and pain in the hands and feet due to such damage

5-Amino-1MQ has been studied for its role as a nicotinamide N-methyltransferase (NNMT) inhibitor, influencing energy expenditure and adiposity-related signaling
NTvG 2002;146: 459-64 5

Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision
