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With a protein this complex, sequence integrity isn't enough folding integrity determines whether it works at all
(2003b)
The prescribing information explicitly states it must be made approximately isotonic prior to use
10.1016/j.taap.2017.08.003 190 YiminS.YanbinG.TaoW.XiaoleiW.JiaxinH.JiayiX.et al (2020)
Int J Adv Life Sci Res
This was corroborated by observations of embryonic lethality in mouse and Caenorhabditis elegans models, with oxidative stress damage shown to be the underlying cause (31)
