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Urruticoechea A, Alemany R, Balart J, Villanueva A, Vials F, Capell G

The pairing models stronger appetite suppression than single-mechanism peptides

In mammals, heterodimer formation between the GCLC and GCLM (modifier) subunits results in the GCL holoenzyme complex which has increased catalytic efficiency over the GCLC subunit alone [74]

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The mTORC1 pathway and ISR are two major amino acid sensing pathways that integrate nutrient availability to cellular adaptations including protein synthesis, metabolism and cell growth 7,8,15,16

doi: 10.1016/j.cbi.2018.12.009