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By leveraging the olfactory epithelium and its associated neural pathways, this method capitalizes on the large surface area, efficient blood flow, and neural connections of the nasal mucosa to provide a relatively non-invasive approach towards efficient peptide delivery into the brain [41-46]

Microbial Ecology in Health & Disease, 2012

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Furthermore, processes that are detrimental to the proper functioning of the brain may be affected due to the increased oxidative stress-related damage and neuroinflammation, leading to altered neuronal signaling and inhibition of neurogenesis

Ethanol was a common treatment in all the cases

Therapeutic administration of a recombinant, sialylated Fc molecule in clinical development similarly activated REST and protected against severe influenza disease, demonstrating that this pathway could be clinically harnessed