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Food intake, drinking pace, individual liver metabolism rate, and medication use all affect the actual outcome

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This difference may be explained by the results of in vitro binding studies, which showed that daratumumab can directly bind CD38 on RBCs, whereas isatuximab requires a cofactor (e.g., a mouse anti-CD38 antibody or a CD38 inhibitor), suggesting masking of the isatuximab epitope on RBCs in some patients [49, 50]

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113b Juni 2011 Additional References Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer

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