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This highlights the need for strategies to overcome the restrictive nature of the BBB and the lack of drug targeting specificity which hinder delivery of adequate drug concentrations in the affected brain regions
Finally, zinc and iron are essential elements for meningococcal survival, so the bacterium develops strategies to acquire them from the host both extracellularly and intracellularly

We also summarize important polymorphisms of the pharmacogenes associated with APAP metabolism

Precision medicine approaches should enroll participants based on biological signatures rather than broad diagnostic categories, including glutathione status, lactate to pyruvate ratios, N acetyl aspartate, NRF2 related profiles, electron transport chain complex activity, and the presence of folate receptor alpha autoantibodies in cerebral folate deficiency

Supplementary Table 2)

10.1016/j.biomaterials.2018.10.016 88 ZhouR.YanL.DongX.ZhuS.ChenK.WuY.et al (2021)
