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doi: 10.1016/j.chemosphere.2010.10.062 36 PriyaM.BalakrishnanV.Kiruthika LakshmA.ArunaR.RavindranK

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Burk RF

Redox control of catalytic activities of membrane-associated protein tyrosine kinases

Mechanism in Copper-Induced Liver Injury Aberrantly increased intracellular levels of copper have been shown to induce oxidative stress through the Fenton reaction [45]

Here, we reveal that the aldehyde derivative of UNC10088 promotes cooperative binding of FBXO22 to NSD2, a histone methyltransferase and oncogenic protein, leading to a cryo-EM structure of the SKP1-CUL1-F-box (SCF)-FBXO22 complex with NSD2
