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Then the paw was immobilized with a plaster splint

2,3 Naltrexone is absorbed orally, and is then metabolized largely via first-pass metabolism in the liver by the enzyme non-cytochrome dehydrogenase to form its active metabolite, 6-naltrexol

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These studies, which involved both pre-treatment and during-treatment dosing regimens, suggest that pharmacological inhibition of GlyT1 has been proposed as a strategy to diminish the rewarding effects of drugs of abuse