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This change in the diurnal regulation of cortisol secretion is linked to regulation of immune responses which is likely to be adaptive in the acute context, but which may be maladaptive with chronic stress (203)

Lyophilization The final step is lyophilization or freeze-drying

While this can be beneficial for people with mood disorders, such as depression, it can sometimes do the opposite of what was intended, and lead to restlessness, anxiety, trouble sleeping, and worry

Kelly KJ, Scarpulla RC

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Three Mechanisms of action