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Although one of these sites is located in the 5 promoter region and the other site in the 3 flanking region, both sites are functional, as they have both been shown to bind the PU.1 nuclear factor in gel mobility shift assays, and both mediate transcription, as assessed by reporter gene assays

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[DOI] [PubMed] [Google Scholar] 68.Ireland DC, Wang CKL, Wilson JA, Gustafson KR, Craik DJ