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A previous study demonstrated that TGRL induces monocyte adhesion to vascular endothelial cells by sequentially activating the expression of PKC, RhoA, focal adhesion kinase, and integrins in vitro , suggesting a mechanism of TGRL remnants-mediated vascular inflammation during atherogenesis (Kawakami et al., 2002)

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Melanomas may also appear as unusual lesions on less sun-exposed areas, such as the palms, soles, or under the nails, especially in individuals with darker skin tones

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DOI: 10.1016/j.soncn.2024.151724 3