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We thank Gong-Min Lin at Metabolomics Core Facility of Agricultural Biotechnology Research Center in Academia Sinica for the assistance of metabolomics analysis and 13 C metabolite tracing

Resultant oxidative DNA base lesions have the potential to mutate some genetic material, which would impair the integrity of the genome by preventing transcription and replication and by generating mutagenesis (116)

Furthermore, they had a 94.6% higher glutathione concentration in their red blood cells, which also led to no statistical difference between the young controls and the elderly subjects in their glutathione levels

This approach can be strategic, allowing the cohorts principal investigator to be flexible for emerging research questions, multidisciplinary opportunities, hypothesis generation, multiple uses, and technological advances (Pero-Gascon et al

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Glutathione protects cells and aids detoxification as a vital non-enzymatic antioxidant