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We have seen a lot of inflammation We have medications to bring those inflammatory markers down

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The elimination of codeine is primarily via the kidneys, and about 90% of an oral dose is excreted by the kidneys within 24 hours of dosing

It also participates in enzyme systems that recycle other antioxidants and maintains the cellular reduced/oxidized (GSH/GSSG) balance, making it central to redox homeostasis

Clinical studies have also identified elevated levels of inflammatory markers and oxidative stress biomarkers in individuals with migraine (7)

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